CO2 Resistant Orbital Shaker Selection and Comparison with Integrated Devices

Introduction

In contrast to static adherent cell cultivation, agitation of shake flasks in a CO2-enriched environment is used to culture mammalian cells in suspension. Cells are either free-floating – as single cells or aggregates – or attached to microcarriers. Applications include the cultivation of embryoid bodies, organoids, the preparation of a starter culture (inoculum) for subsequent larger cell production in bioreactors (scale up), or the expression of complex recombinant proteins. One of the most prominent examples of use is the production of therapeutic rec

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